Sensitivity analysis of only patients with atrial fibrillation demonstrated rivaroxaban had higher overall rates of GI bleeding than apixaban (3.2 vs. Rivaroxaban was associated with higher rates of upper GI bleeding compared with dabigatran (1 vs. Rivaroxaban was associated with numerically higher rates of overall GI bleeding (3.2 vs. 2.5 events per 100 person-years hazard ratio, 1.42 95% confidence interval, 1.04-1.93). Rivaroxaban demonstrated higher rates of overall GI bleeding compared to apixaban (3.2 vs. Only 130 GI bleeding events were identified using ICD-10 codes alone, resulting in a specificity of 99.9% and sensitivity of 53% for this methodology compared with the method utilized by the investigators. A total of 241 GI bleeding events were identified, 135 originating from the lower GI tract, and 146 classified as major bleeding by International Society on Thrombosis and Haemostasis criteria. Rivaroxaban was the most filled DOAC prescription (54.8%), followed by apixaban (36.8%), then dabigatran (8.4%) with a mean follow-up time of 1.6 years, 1.2 years, and 1.8 years, respectively.
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